![]() ![]() SonaCare Medical, Indianapolis, Indiana, USA In this lecture, present status of focused ultrasound for the treatment of localized prostate cancer ablation will be discussed. We will also review the process of expanding approved FUS applications, either via investigator- or industry-initiated studies or through off-label clinical use. The impact of these trials on the evidence base, and thus on adoption by users and coverage by insurers will be compared. Stanford School of Medicine, Stanford, California, USA In this lecture, we will compare the design of clinical trials that led to approval of MR guided focused ultrasound for the treatment of uterine fibroids and osseous metastases. This presentation will explore the mechanisms associated with histotripsy along with the tissue effects and the wide range of potential applications for this mechanical disruption method. These effects range from petechial haemorrhage to complete cellular disruption, termed Histotripsy, depending on ultrasound parameters. Basic Radiological Sciences Division, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA When exposed to sufficiently high ultrasound pressures, microbubbles can be generated spontaneously in tissue and undergo inertial cavitation where collapses result in physical effects.
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